COG6

Across TCGA patient cohorts, COG6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG6-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and EGFR_pY1068. Each is linked with COG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG6-to-partner and partner-to-COG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by COG6-low versus COG6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG6→partner) and Y-score (partner→COG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.157	+2.169	.003	.003	3	2
UCEC	14-3-3_beta →	-0.093	-2.432	.013	.018	3	1
UCEC	EGFR_pY1068 →	-0.293	-3.807	.001	<.001	3	1
UCEC	eIF4E →	+0.176	+2.820	.026	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.104	-1.690	.026	.042	3	1
UCEC	Heregulin →	-0.114	-2.986	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

C-Raf by COG6 expression — UCEC

Explore this box plot interactively →