COG3

Across TCGA pan-cancer cohorts, COG3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COG3 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher COG3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COG3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, BRCA, and LUAD are the cancer types where COG3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.122	0.811	<.001	36	view →
BRCA	OS	Median	All	0.445	0.926	<.001	36	view →
LUAD	DFS	Median	All	0.200	0.815	<.001	21	view →
KIRP	OS	Median	All	0.199	0.903	<.001	15	view →
UCEC	DFS	Median	II,III,IV	0.915	0.306	.022	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COG3–KIRC (OS)

Open the KIRC breakdown →