COG3

Across TCGA pan-cancer cohorts, COG3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COG3 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COG3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COG3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where COG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.976	0.807	.005	26	view →
LSCC	DFS	Tertile	II,III,IV	0.535	0.848	.008	8	view →
LUAD	OS	Tertile	III,IV	0.879	0.315	.011	7	view →
PDAC	DFS	Quartile	All	0.501	0.344	.018	4	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	3	view →
GBM	DFS	Quartile	All	0.288	0.456	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COG3–UCEC (DFS)

Open the UCEC breakdown →