COG3

Across TCGA patient cohorts, COG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,668 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COG3-associated proteins across cancer lineages are COG4, ARHGEF7, and SUGT1. Each is linked with COG3 in more than 7 cancer types. Because this analysis shows association rather than direction, both COG3-to-partner and partner-to-COG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG3 versus COG4 in BRCA, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COG3→partner) and Y-score (partner→COG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COG4 →	+0.292	+0.423	<.001	<.001	3	8
LSCC	ARHGEF7 →	+0.268	+0.444	<.001	<.001	3	7
LSCC	SUGT1 →	+0.300	+0.377	<.001	.001	3	7
BRCA	COG2 →	+0.390	+0.555	<.001	<.001	3	7
OV	TSC22D1 →	+0.634	+0.578	.001	<.001	3	7
BRCA	SNF8 →	+0.233	+0.448	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,668 associations by consensus.

COG3 vs COG4 — BRCA

Explore this scatter interactively →