COG3

Across TCGA patient cohorts, COG3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COG3-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with COG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG3-to-partner and partner-to-COG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COG3-low versus COG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG3→partner) and Y-score (partner→COG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.978	+3.321	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.109	-3.558	.003	.002	3	1
UCEC	eEF2 →	+0.298	+2.999	.026	.035	3	1
UCEC	ERK2 →	+0.182	+1.700	.012	.042	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-2.649	.001	<.001	3	1
UCEC	MEK1 →	+0.436	+2.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by COG3 expression — UCEC

Explore this box plot interactively →