COG2

Across TCGA pan-cancer cohorts, COG2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated COG2 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher COG2 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated COG2 expression acts as an unfavorable survival marker, although some lineages such as STAD and LUSC show a favorable association.

STAD and LUSC are the cancer types where COG2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	IV	1.000	0.299	.047	3	view →
LUSC	DFS	Median	All	0.752	0.368	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

COG2–STAD (OS)

Open the STAD breakdown →