COG2

Across TCGA cell cohorts, COG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,954 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible COG2-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Nuclear pore organization, and Negative regulation of chromosome condensation. Each is linked with COG2 in more than 14 cancer types. Because this analysis shows association rather than direction, both COG2-to-partner and partner-to-COG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by COG2-low versus COG2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COG2→partner) and Y-score (partner→COG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Establishment of protein localization to endoplasmic reticulum membrane →	+0.101	+0.679	.004	.001	3	15
BONE	Nuclear pore organization →	+0.157	+0.640	<.001	<.001	3	14
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.170	+0.808	<.001	<.001	3	13
BLOOD_Myeloma	mRNA 3'-end processing →	+0.096	+1.124	.001	<.001	3	13
LIVER	Positive regulation of DNA repair →	+0.082	+0.837	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription elongation →	+0.092	+0.837	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,954 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by COG2 expression — LUNG_SCLC

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