COG1

Across TCGA pan-cancer cohorts, COG1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of COG1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where COG1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types COG1 is over-expressed in tumor.

CCRCC, LUAD, and COAD are the cancer types where COG1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COG1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.167	<.001	11	view →
LUAD	Female	All	+0.465	<.001	9	view →
COAD	All	All	+0.103	<.001	9	view →
HNSC	All	IV	+0.207	.004	6	view →
LSCC	Male	All	+0.144	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

COG1–CCRCC

Open the CCRCC breakdown →