COBLL1

Across TCGA pan-cancer cohorts, COBLL1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COBLL1 data layer compared with 22 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher COBLL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COBLL1 expression acts as an unfavorable survival marker.

LGG, PRAD, and LIHC are the cancer types where COBLL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.195	0.889	<.001	6	view →
PRAD	DFS	Median	All	0.617	0.886	.022	6	view →
LIHC	OS	Median	All	0.292	0.694	.003	6	view →
LUSC	OS	Median	All	0.192	0.724	.040	3	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COBLL1–LGG (OS)

Open the LGG breakdown →