COBLL1

Across TCGA pan-cancer cohorts, COBLL1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COBLL1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COBLL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COBLL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and COAD are the cancer types where COBLL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.950	0.761	.002	18	view →
CCRCC	DFS	Median	III,IV	0.795	0.555	.008	14	view →
COAD	DFS	Tertile	All	1.000	0.913	.043	12	view →
GBM	DFS	Tertile	All	0.210	0.469	.002	11	view →
HNSC	DFS	Median	All	0.732	0.558	.025	5	view →
PDAC	OS	Tertile	III,IV	0.932	0.328	.031	4	view →
LUAD	OS	Quartile	III,IV	0.849	0.436	.021	3	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.890	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COBLL1–UCEC (DFS)

Open the UCEC breakdown →