COBLL1

Across TCGA patient cohorts, COBLL1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COBLL1-associated genes across cancer lineages are Bax, eIF4G, and ERK2. Each is linked with COBLL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COBLL1-to-partner and partner-to-COBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by COBLL1-low versus COBLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBLL1→partner) and Y-score (partner→COBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.173	+1.447	.010	.002	3	3
UCEC	eIF4G →	+0.180	+1.280	.039	.049	3	2
UCEC	ERK2 →	+0.162	+1.632	.002	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.273	.010	.007	3	2
UCEC	GAPDH →	+0.302	+1.765	.045	.011	3	2
UCEC	INPP4B →	-0.221	-1.716	.015	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Bax by COBLL1 expression — UCEC

Explore this box plot interactively →