COBLL1

Across TCGA cell cohorts, COBLL1 mutation is significantly associated with the RNA expression of many other genes, with 1,826 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COBLL1-associated genes across cancer lineages are CSPP1, NUP88, and FBXO30. Each is linked with COBLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COBLL1-to-partner and partner-to-COBLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSPP1 grouped by COBLL1-low versus COBLL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBLL1→partner) and Y-score (partner→COBLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSPP1 →	+0.537	+2.850	.001	<.001	3	2
LARGE_INTESTINE	NUP88 →	+0.634	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	FBXO30 →	+0.436	+2.850	.002	<.001	3	2
LARGE_INTESTINE	CAAP1 →	+0.510	+3.459	.003	.001	3	2
LARGE_INTESTINE	TNFSF9 →	+1.296	+2.158	.001	.004	3	2
LARGE_INTESTINE	LRRC41 →	+0.594	+2.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,826 associations by consensus.

CSPP1 by COBLL1 expression — LARGE_INTESTINE

Explore this box plot interactively →