COBL

Across TCGA pan-cancer cohorts, COBL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COBL data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COBL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COBL expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where COBL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.379	0.200	.004	33	view →
CCRCC	OS	Quartile	All	0.955	0.706	.005	24	view →
LUAD	DFS	Tertile	All	0.831	0.977	.010	23	view →
LSCC	DFS	Median	II,III,IV	0.837	1.000	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COBL–PDAC (DFS)

Open the PDAC breakdown →