COBL

Across TCGA patient cohorts, COBL protein abundance is significantly associated with the RNA expression of many other genes, with 15,777 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COBL-associated genes across cancer lineages are CHDH, GPD1, and ADAM12. Each is linked with COBL in more than 4 cancer types. Because this analysis shows association rather than direction, both COBL-to-partner and partner-to-COBL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COBL versus CHDH in BRCA, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBL→partner) and Y-score (partner→COBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHDH →	+1.059	+0.645	<.001	<.001	3	5
CCRCC	GPD1 →	+1.391	+0.461	<.001	<.001	3	5
OV	ADAM12 →	-2.583	-1.475	<.001	.005	3	4
OV	TMEM158 →	-2.703	-1.613	.002	.002	3	4
OV	HNF1B →	+2.272	+1.522	.001	.004	3	4
CCRCC	MTARC2 →	+0.785	+0.508	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,777 associations by consensus.

COBL vs CHDH — BRCA

Explore this scatter interactively →