COBL

Across TCGA patient cohorts, COBL mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COBL-associated genes across cancer lineages are 4E-BP1_pS65, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with COBL in more than 3 cancer types. Because this analysis shows association rather than direction, both COBL-to-partner and partner-to-COBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by COBL-low versus COBL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBL→partner) and Y-score (partner→COBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pS65 →	+0.204	+2.392	.003	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.028	+3.016	.001	.018	3	4
UCEC	Cyclin-B1 →	+0.717	+2.222	<.001	<.001	3	4
BLCA	eEF2 →	+0.377	+2.187	.001	.034	3	3
SKCM	MYH11 →	-0.811	-3.700	.007	.001	3	3
UCEC	Bak →	+0.176	+1.662	.022	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

4E-BP1_pS65 by COBL expression — SKCM

Explore this box plot interactively →