COBL

Across TCGA cell cohorts, COBL mutation is significantly associated with the RNA expression of many other genes, with 540 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COBL-associated genes across cancer lineages are DYNAP, CA2, and SRMS. Each is linked with COBL in more than 1 cancer types. Because this analysis shows association rather than direction, both COBL-to-partner and partner-to-COBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNAP grouped by COBL-low versus COBL-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBL→partner) and Y-score (partner→COBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DYNAP →	+0.083	+2.959	<.001	.004	3	2
LARGE_INTESTINE	CA2 →	+1.596	+3.321	.001	.003	3	2
LARGE_INTESTINE	SRMS →	+0.853	+2.743	<.001	.001	3	2
LARGE_INTESTINE	USP8 →	+0.479	+3.169	.002	.006	3	2
LARGE_INTESTINE	HIPK1 →	+0.610	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	DALRD3 →	+0.338	+2.043	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 540 associations by consensus.

DYNAP by COBL expression — STOMACH

Explore this box plot interactively →