COBL

Across TCGA cell cohorts, COBL mutation is significantly associated with the mutation status of many other genes, with 3,995 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COBL-associated genes across cancer lineages are MYO9B, UNC80, and KDM5A. Each is linked with COBL in more than 5 cancer types. Because this analysis shows association rather than direction, both COBL-to-partner and partner-to-COBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO9B grouped by COBL-low versus COBL-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COBL→partner) and Y-score (partner→COBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MYO9B →	+3.539	+4.660	.002	.002	1	6
OVARY	UNC80 →	+2.667	+4.376	<.001	<.001	1	6
BLOOD_Lymphoma	KDM5A →	+3.938	+3.731	<.001	<.001	1	5
SOFT_TISSUE	KIAA1549L →	+5.307	+4.651	<.001	<.001	1	5
SOFT_TISSUE	FAM47A →	+4.307	+4.307	.001	.001	1	5
STOMACH	KNDC1 →	+3.177	+3.531	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,995 associations by consensus.

MYO9B by COBL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →