COA8

Across TCGA cell cohorts, COA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,962 significant associations in total. BONE shows the largest number of these associations.

The most reproducible COA8-associated GO terms across cancer lineages are Regulation of protein ubiquitination, Regulation of ubiquitin-dependent protein catabolic process, and Regulation of actin filament depolymerization. Each is linked with COA8 in more than 7 cancer types. Because this analysis shows association rather than direction, both COA8-to-partner and partner-to-COA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein ubiquitination grouped by COA8-low versus COA8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COA8→partner) and Y-score (partner→COA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of protein ubiquitination →	+0.061	+0.499	<.001	<.001	3	8
OVARY	Regulation of ubiquitin-dependent protein catabolic process →	+0.060	+0.826	<.001	<.001	3	8
BONE	Regulation of actin filament depolymerization →	+0.095	+0.623	.006	.006	3	8
LARGE_INTESTINE	Vesicle tethering to Golgi →	+0.078	+0.551	.004	.003	3	8
LIVER	Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	+0.177	+0.766	.008	.008	3	7
LIVER	Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	+0.177	+0.766	.008	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,962 associations by consensus.

Regulation of protein ubiquitination by COA8 expression — OVARY

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