COA6

Across TCGA pan-cancer cohorts, COA6 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated COA6 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher COA6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COA6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, HNSC, and COAD are the cancer types where COA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.525	0.300	<.001	95	view →
HNSC	DFS	Median	II,III,IV	0.885	0.994	.001	33	view →
COAD	DFS	Median	All	1.000	0.884	.017	30	view →
LUAD	OS	Quartile	III,IV	0.819	0.216	.006	12	view →
CCRCC	DFS	Median	All	0.642	0.837	.019	11	view →
UCEC	DFS	Quartile	III,IV	1.000	0.359	.040	8	view →
GBM	DFS	Quartile	All	0.866	0.606	.047	1	view →
LSCC	DFS	Median	All	0.611	0.807	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

COA6–PDAC (DFS)

Open the PDAC breakdown →