COA5

Across TCGA pan-cancer cohorts, COA5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated COA5 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher COA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COA5 expression acts as an unfavorable survival marker.

BLCA, SKCM, and UCEC are the cancer types where COA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.188	0.710	.004	15	view →
SKCM	DFS	Median	All	0.046	0.757	<.001	15	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

COA5–BLCA (OS)

Open the BLCA breakdown →