Across TCGA pan-cancer cohorts, COA5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COA5 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COA5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated COA5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where COA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.756	.003	27	view →
PDAC	DFS	Quartile	All	0.661	0.269	.001	19	view →
LSCC	DFS	Tertile	All	0.861	0.602	.006	16	view →
HNSC	DFS	Quartile	All	0.655	0.912	.007	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COA5 tumor-vs-normal RNA expression · all COA5 data types