Across TCGA patient cohorts, COA5 mutation is significantly associated with the RNA expression of many other genes, with 119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COA5-associated genes across cancer lineages are RNA5-8SP7, MIR1263, and MIR1283-1. Each is linked with COA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both COA5-to-partner and partner-to-COA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA5→partner) and Y-score (partner→COA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5-8SP7 →	+0.452	+4.132	<.001	.009	3	2
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	1
COAD	RNA5SP409 →	+0.345	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

Exploration

COA5 survival (RNA) · tumor vs normal (RNA) · all COA5 data types