COA4

Across TCGA pan-cancer cohorts, COA4 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated COA4 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated COA4 expression acts as an unfavorable survival marker.

LUAD are the cancer types where COA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.098	0.768	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

COA4–LUAD (DFS)

Open the LUAD breakdown →