COA4

Across TCGA pan-cancer cohorts, COA4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COA4 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COA4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COA4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where COA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	42	view →
HNSC	DFS	Median	All	0.903	1.000	<.001	28	view →
PDAC	DFS	Tertile	III,IV	0.889	0.214	.001	18	view →
LUAD	OS	Tertile	III,IV	0.721	0.193	.003	16	view →
LSCC	OS	Quartile	II,III,IV	0.945	0.571	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COA4–CCRCC (DFS)

Open the CCRCC breakdown →