Across TCGA pan-cancer cohorts, COA3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated COA3 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher COA3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COA3 expression acts as an unfavorable survival marker.

SARC are the cancer types where COA3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.174	0.745	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: COA3 tumor-vs-normal RNA expression · all COA3 data types