Across TCGA pan-cancer cohorts, COA3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COA3 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COA3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COA3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where COA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.869	0.478	.005	19	view →
LUAD	OS	Median	All	0.888	1.000	.004	4	view →
PDAC	DFS	Quartile	III,IV	0.517	0.939	.011	3	view →
GBM	OS	Quartile	All	0.643	0.311	.039	3	view →
CCRCC	DFS	Median	IV	0.382	0.932	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: COA3 tumor-vs-normal RNA expression · all COA3 data types