Across TCGA patient cohorts, COA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,438 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COA3-associated proteins across cancer lineages are PLEKHO2_T364, PSME3, and SAMSN1. Each is linked with COA3 in more than 5 cancer types. Because this analysis shows association rather than direction, both COA3-to-partner and partner-to-COA3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COA3→partner) and Y-score (partner→COA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEKHO2_T364 →	-0.402	-0.251	<.001	<.001	3	6
LSCC	PSME3 →	+0.484	+0.736	<.001	<.001	3	6
GBM	SAMSN1 →	-0.597	-0.248	<.001	.006	3	6
LUAD	CKAP4_S26 →	-0.716	-0.433	<.001	.002	3	6
GBM	DOK3 →	-0.398	-0.229	<.001	<.001	3	6
LUAD	EVI2B →	-0.630	-0.661	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,438 associations by consensus.

Exploration

COA3 survival (RNA) · tumor vs normal (RNA) · all COA3 data types