Across TCGA patient cohorts, COA3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,696 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COA3-associated genes across cancer lineages are RAB33A, C1R, and SLC7A7. Each is linked with COA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both COA3-to-partner and partner-to-COA3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA3→partner) and Y-score (partner→COA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAB33A →	-0.765	-0.370	<.001	<.001	3	5
UCEC	C1R →	-0.983	-0.366	<.001	<.001	3	5
BRCA	SLC7A7 →	-0.677	-0.611	<.001	<.001	3	5
LSCC	C3AR1 →	-0.722	-0.418	<.001	<.001	3	5
HNSC	ALDH5A1 →	+0.795	+0.333	.001	.002	3	4
BRCA	TYROBP →	-0.711	-0.486	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,696 associations by consensus.

Exploration

COA3 survival (RNA) · tumor vs normal (RNA) · all COA3 data types