Across TCGA patient cohorts, COA3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COA3-associated genes across cancer lineages are BNIP3P4, RN7SL575P, and RPL22P6. Each is linked with COA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COA3-to-partner and partner-to-COA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA3→partner) and Y-score (partner→COA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P4 →	+0.172	+4.484	<.001	.009	3	1
UCEC	RN7SL575P →	+0.358	+4.349	.003	.007	3	1
UCEC	RPL22P6 →	+0.169	+5.226	<.001	.003	3	1
UCEC	RNA5SP235 →	+0.281	+5.722	.008	.001	3	1
UCEC	RNU1-138P →	+0.570	+5.003	<.001	.002	3	1
UCEC	RNU6-784P →	+0.433	+5.520	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

COA3 survival (RNA) · tumor vs normal (RNA) · all COA3 data types