Across TCGA cell cohorts, COA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COA3-associated GO terms across cancer lineages are Mitochondrial translation, Mitochondrial respiratory chain complex assembly, and Response to staurosporine. Each is linked with COA3 in more than 9 cancer types. Because this analysis shows association rather than direction, both COA3-to-partner and partner-to-COA3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COA3→partner) and Y-score (partner→COA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Mitochondrial translation →	+0.076	+0.694	<.001	<.001	3	9
LARGE_INTESTINE	Mitochondrial respiratory chain complex assembly →	+0.065	+0.616	<.001	.007	2	10
LARGE_INTESTINE	Response to staurosporine →	+0.118	+0.690	.003	.002	3	8
LARGE_INTESTINE	Cellular response to staurosporine →	+0.118	+0.690	.003	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Protein insertion into mitochondrial outer membrane →	+0.102	+0.801	<.001	.001	3	8
BONE	Cornification →	+0.401	+0.695	.003	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,821 associations by consensus.

Exploration

COA3 survival (RNA) · tumor vs normal (RNA) · all COA3 data types