COA1

Across TCGA pan-cancer cohorts, COA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COA1 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher COA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated COA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where COA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.534	0.849	.002	42	view →
PDAC	DFS	Tertile	III,IV	0.984	0.410	.024	12	view →
UCEC	OS	Median	III,IV	0.872	0.306	.047	4	view →
LUAD	DFS	Median	III,IV	0.928	0.466	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COA1–CCRCC (OS)

Open the CCRCC breakdown →