COA1

Across TCGA patient cohorts, COA1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,094 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COA1-associated genes across cancer lineages are CARD8-AS1, ITGA4, and WIPF1. Each is linked with COA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both COA1-to-partner and partner-to-COA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COA1 versus CARD8-AS1 in BRCA, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA1→partner) and Y-score (partner→COA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CARD8-AS1 →	-0.740	-0.540	<.001	<.001	3	6
BRCA	ITGA4 →	-0.958	-0.396	<.001	.005	3	5
BRCA	WIPF1 →	-1.133	-0.615	<.001	<.001	3	5
COAD	ZEB2 →	-0.749	-0.382	.003	.006	3	5
COAD	C1orf54 →	-0.999	-0.472	.005	.003	3	5
BRCA	GIMAP6 →	-1.232	-0.558	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,094 associations by consensus.

COA1 vs CARD8-AS1 — BRCA

Explore this scatter interactively →