COA1

Across TCGA patient cohorts, COA1 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COA1-associated genes across cancer lineages are KMT2B, RN7SKP157, and WFDC9. Each is linked with COA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COA1-to-partner and partner-to-COA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT2B grouped by COA1-low versus COA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA1→partner) and Y-score (partner→COA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KMT2B →	+0.471	+3.470	.009	.003	3	1
BRCA	RN7SKP157 →	+0.138	+8.055	<.001	.007	3	1
BLCA	WFDC9 →	+0.055	+4.314	.001	.009	3	1
BLCA	RNU6-336P →	+0.300	+4.433	<.001	.007	3	1
BLCA	TRAJ24 →	+0.792	+3.926	<.001	.005	3	1
UCEC	LINC00294 →	+0.573	+3.209	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

KMT2B by COA1 expression — UCEC

Explore this box plot interactively →