COA1

Across TCGA patient cohorts, COA1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COA1-associated genes across cancer lineages are MEK1, FASN, and TFRC. Each is linked with COA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COA1-to-partner and partner-to-COA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by COA1-low versus COA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COA1→partner) and Y-score (partner→COA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.580	+2.999	.006	.035	3	1
UCEC	FASN →	+0.447	+3.000	.049	.037	1	1
UCEC	TFRC →	+0.726	+3.000	.018	.037	1	1
UCEC	Cyclin-B1 →	+0.737	+3.000	.023	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MEK1 by COA1 expression — UCEC

Explore this box plot interactively →