COA1

Across TCGA cell cohorts, COA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,976 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COA1-associated GO terms across cancer lineages are Mismatch repair, Mitochondrial electron transport, NADH to ubiquinone, and Positive regulation of isotype switching to IgG isotypes. Each is linked with COA1 in more than 11 cancer types. Because this analysis shows association rather than direction, both COA1-to-partner and partner-to-COA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mismatch repair grouped by COA1-low versus COA1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COA1→partner) and Y-score (partner→COA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Mismatch repair →	+0.044	+0.485	<.001	.001	3	12
BLOOD_Myeloma	Mitochondrial electron transport, NADH to ubiquinone →	+0.088	+0.821	.001	.001	3	11
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.123	+0.705	<.001	<.001	3	10
STOMACH	Regulation of isotype switching to IgA isotypes →	+0.098	+0.421	.007	.005	3	10
STOMACH	Positive regulation of isotype switching to IgA isotypes →	+0.098	+0.421	.007	.005	3	10
BONE	Protein import into nucleus →	+0.072	+0.896	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,976 associations by consensus.

Mismatch repair by COA1 expression — SKIN

Explore this box plot interactively →