CNTNAP3B

Across TCGA cell cohorts, CNTNAP3B mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTNAP3B-associated genes across cancer lineages are GRM6, NPBWR2, and HMGB4. Each is linked with CNTNAP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTNAP3B-to-partner and partner-to-CNTNAP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM6 grouped by CNTNAP3B-low versus CNTNAP3B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTNAP3B→partner) and Y-score (partner→CNTNAP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM6 →	+0.051	+2.378	.003	.006	3	2
PANCREAS	NPBWR2 →	+0.023	+5.000	<.001	.006	3	1
PANCREAS	HMGB4 →	+0.015	+5.000	.008	.006	3	1
PANCREAS	KRTAP20-2 →	+0.126	+5.614	<.001	.002	3	1
PANCREAS	ZIM2 →	+0.059	+5.000	<.001	.006	3	1
CNS	IL21 →	+0.028	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

GRM6 by CNTNAP3B expression — LARGE_INTESTINE

Explore this box plot interactively →