CNTNAP2

Across TCGA patient cohorts, CNTNAP2 mutation is significantly associated with the total protein of many other genes, with 108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTNAP2-associated genes across cancer lineages are Cyclin-B1, ER-alpha, and Bap1-c-4. Each is linked with CNTNAP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CNTNAP2-to-partner and partner-to-CNTNAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CNTNAP2-low versus CNTNAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTNAP2→partner) and Y-score (partner→CNTNAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.479	+2.201	<.001	<.001	3	6
CESC	ER-alpha →	-0.669	-3.169	.027	.017	3	4
STAD	Bap1-c-4 →	+0.272	+1.765	.028	.012	3	4
UCEC	STAT3_pY705 →	-0.245	-1.077	<.001	.007	3	4
BRCA	ASNS →	+0.447	+3.169	.018	.020	3	4
COAD	Cyclin-E1 →	+0.236	+2.807	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

Cyclin-B1 by CNTNAP2 expression — UCEC

Explore this box plot interactively →