CNTNAP2

Across TCGA cell cohorts, CNTNAP2 mutation is significantly associated with the RNA expression of many other genes, with 511 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTNAP2-associated genes across cancer lineages are OR51B4, IL2RA, and SLC35G3. Each is linked with CNTNAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNTNAP2-to-partner and partner-to-CNTNAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51B4 grouped by CNTNAP2-low versus CNTNAP2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTNAP2→partner) and Y-score (partner→CNTNAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR51B4 →	+0.768	+3.376	.001	.009	3	3
CNS	IL2RA →	+0.097	+2.877	<.001	.003	3	2
BLOOD_Leukemia	SLC35G3 →	+0.032	+2.704	<.001	.005	3	2
LARGE_INTESTINE	HMGXB4 →	+0.516	+2.850	.002	<.001	3	2
LARGE_INTESTINE	TRMU →	+0.499	+2.158	.004	.004	3	2
LARGE_INTESTINE	ZNF484 →	+0.397	+2.158	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 511 associations by consensus.

OR51B4 by CNTNAP2 expression — LUNG_SCLC

Explore this box plot interactively →