CNTN5

Across TCGA patient cohorts, CNTN5 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CNTN5-associated genes across cancer lineages are 4E-BP1, CDK1, and GSK3-a-b. Each is linked with CNTN5 in more than 4 cancer types. Because this analysis shows association rather than direction, both CNTN5-to-partner and partner-to-CNTN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CNTN5-low versus CNTN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTN5→partner) and Y-score (partner→CNTN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.293	+2.444	<.001	.001	2	5
LUAD	CDK1 →	+0.089	+1.700	.016	.040	3	3
LUSC	GSK3-a-b →	+0.153	+2.009	.013	.005	3	3
UCEC	Rab11 →	-0.124	-1.321	.004	.012	3	3
UCEC	Tuberin →	+0.322	+1.530	<.001	.004	3	3
COAD	ATM →	-0.473	-2.807	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

4E-BP1 by CNTN5 expression — UCEC

Explore this box plot interactively →