CNTN3

Across TCGA patient cohorts, CNTN3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTN3-associated genes across cancer lineages are PCNA, eIF4E, and AMPK_alpha. Each is linked with CNTN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNTN3-to-partner and partner-to-CNTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CNTN3-low versus CNTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTN3→partner) and Y-score (partner→CNTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.157	+1.678	.013	.019	3	4
UCEC	eIF4E →	+0.176	+1.637	.004	.001	3	3
LUAD	AMPK_alpha →	+0.230	+3.033	<.001	.017	3	2
LUAD	Smac →	+0.348	+2.000	.007	.031	3	2
LUAD	Synaptophysin →	+0.717	+2.183	.024	.033	3	2
LUSC	MSH6 →	+0.376	+2.468	.034	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PCNA by CNTN3 expression — UCEC

Explore this box plot interactively →