CNTFR

Across TCGA patient cohorts, CNTFR mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTFR-associated genes across cancer lineages are eEF2, ERK2, and GAPDH. Each is linked with CNTFR in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTFR-to-partner and partner-to-CNTFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CNTFR-low versus CNTFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTFR→partner) and Y-score (partner→CNTFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.347	+3.000	.031	.036	3	1
UCEC	ERK2 →	+0.177	+2.700	.042	.006	3	1
UCEC	GAPDH →	+0.608	+2.459	.012	.019	3	1
UCEC	Ku80 →	+0.266	+2.013	.012	.018	3	1
UCEC	c-Met_pY1235 →	+0.120	+3.469	<.001	.002	3	1
UCEC	4E-BP1 →	+0.361	+3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eEF2 by CNTFR expression — UCEC

Explore this box plot interactively →