CNTFR

Across TCGA cell cohorts, CNTFR mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNTFR-associated genes across cancer lineages are SEMG2, DEFA4, and TBC1D21. Each is linked with CNTFR in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTFR-to-partner and partner-to-CNTFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by CNTFR-low versus CNTFR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTFR→partner) and Y-score (partner→CNTFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEMG2 →	+0.401	+2.878	.005	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+3.921	<.001	.001	3	1
LARGE_INTESTINE	TMEM95 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CCDC73 →	+0.038	+3.520	.005	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SEMG2 by CNTFR expression — LARGE_INTESTINE

Explore this box plot interactively →