CNST

Across TCGA pan-cancer cohorts, CNST mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CNST’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CNST mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CNST is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and COAD are the cancer types where CNST tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNST mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.268	<.001	7	view →
LSCC	All	All	−0.117	<.001	6	view →
COAD	All	All	−0.691	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CNST–LUAD

Open the LUAD breakdown →