CNPPD1

Across TCGA pan-cancer cohorts, CNPPD1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CNPPD1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CNPPD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNPPD1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and KICH are the cancer types where CNPPD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNPPD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	+1.031	<.001	9	view →
THCA	All	IV	−0.990	<.001	9	view →
KICH	All	All	−0.555	<.001	9	view →
BRCA	All	III,IV	+0.395	<.001	8	view →
COAD	Female	II,III,IV	−0.513	<.001	7	view →
STAD	Male	II,III,IV	+0.683	.002	6	view →
LUSC	All	II,III,IV	−0.590	<.001	6	view →
LUAD	All	All	−0.221	.001	4	view →
CHOL	Female	All	+1.860	<.001	3	view →
BLCA	Male	III,IV	−0.750	.016	2	view →
ESCA	Female	All	+1.006	.044	1	view →
KIRC	Female	All	+0.454	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CNPPD1–LIHC

Open the LIHC breakdown →