CNOT8

Across TCGA pan-cancer cohorts, CNOT8 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CNOT8’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CNOT8 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CNOT8 is over-expressed in tumor.

CCRCC, LUAD, and HNSC are the cancer types where CNOT8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNOT8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.538	<.001	11	view →
LUAD	Male	II,III,IV	+0.321	<.001	9	view →
HNSC	Male	II,III,IV	+0.393	<.001	8	view →
PDAC	Female	All	+0.355	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CNOT8–CCRCC

Open the CCRCC breakdown →