CNOT8

Across TCGA patient cohorts, CNOT8 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,004 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CNOT8-associated proteins across cancer lineages are RPL7, SLU7, and NUDCD2. Each is linked with CNOT8 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT8 versus RPL7 in GBM, with a Pearson correlation of -0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL7 →	-0.362	-0.266	<.001	<.001	3	4
GBM	SLU7 →	+0.244	+0.255	<.001	<.001	3	4
BRCA	NUDCD2 →	+0.345	+0.405	<.001	.001	3	4
PDAC	PAIP2B →	-0.663	-0.303	.002	.001	3	4
PDAC	RASA1 →	+0.485	+0.390	<.001	<.001	3	4
GBM	RBM22 →	+0.281	+0.274	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,004 associations by consensus.

CNOT8 vs RPL7 — GBM

Explore this scatter interactively →