CNOT8

Across TCGA patient cohorts, CNOT8 protein abundance is significantly associated with the RNA expression of many other genes, with 3,354 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CNOT8-associated genes across cancer lineages are CNOT7, INTS10, and CHMP7. Each is linked with CNOT8 in more than 6 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT8 versus CNOT7 in BRCA, with a Pearson correlation of -0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNOT7 →	-0.563	-0.486	<.001	<.001	3	7
BRCA	INTS10 →	-0.529	-0.406	<.001	<.001	3	5
HNSC	CHMP7 →	-0.418	-0.256	.009	.002	3	5
BRCA	VPS37A →	-0.512	-0.374	<.001	<.001	3	5
HNSC	CCAR2 →	-0.423	-0.240	.001	.004	3	5
BRCA	PCM1 →	-0.489	-0.385	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,354 associations by consensus.

CNOT8 vs CNOT7 — BRCA

Explore this scatter interactively →