CNOT8

Across TCGA patient cohorts, CNOT8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT8-associated genes across cancer lineages are FoxM1, Ku80, and STAT3_pY705. Each is linked with CNOT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CNOT8-low versus CNOT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.333	+3.321	.013	.010	3	1
UCEC	Ku80 →	+0.250	+2.183	.043	.035	3	1
UCEC	STAT3_pY705 →	-0.412	-3.321	.002	.010	3	1
UCEC	BRD4 →	+0.363	+3.010	.009	.019	2	1
UCEC	ACVRL1 →	-0.225	-3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FoxM1 by CNOT8 expression — UCEC

Explore this box plot interactively →