CNOT8

Across TCGA cell cohorts, CNOT8 RNA expression is significantly associated with the RNA expression of many other genes, with 10,687 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CNOT8-associated genes across cancer lineages are MATR3, RBM27, and ELF2. Each is linked with CNOT8 in more than 16 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT8 versus MATR3 in UPPER_AERODIGESTIVE_TRACT, with a Pearson correlation of 0.84.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MATR3 →	+0.788	+0.702	<.001	<.001	3	17
BONE	RBM27 →	+0.919	+0.521	.003	.002	3	17
URINARY_TRACT	ELF2 →	+1.151	+1.024	<.001	<.001	3	17
BLOOD_Lymphoma	FBXO38 →	+0.853	+0.892	<.001	<.001	3	16
LUNG_NSCLC_LUSC	RBM22 →	+0.825	+1.300	<.001	<.001	3	16
OESOPHAGUS	CNOT6 →	+0.827	+1.181	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,687 associations by consensus.

CNOT8 vs MATR3 — UPPER_AERODIGESTIVE_TRACT

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