CNOT8

Across TCGA cell cohorts, CNOT8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,502 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNOT8-associated GO terms across cancer lineages are Regulation of transcription initiation by RNA polymerase II, Positive regulation of stem cell population maintenance, and Protein sumoylation. Each is linked with CNOT8 in more than 12 cancer types. Because this analysis shows association rather than direction, both CNOT8-to-partner and partner-to-CNOT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription initiation by RNA polymerase II grouped by CNOT8-low versus CNOT8-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT8→partner) and Y-score (partner→CNOT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of transcription initiation by RNA polymerase II →	+0.055	+0.768	<.001	.001	3	13
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.077	+0.392	.004	<.001	3	13
LUNG_SCLC	Protein sumoylation →	+0.085	+0.476	<.001	.001	3	12
BLOOD_Myeloma	Vesicle coating →	+0.075	+0.621	.003	.001	3	11
BLOOD_Leukemia	Regulation of cytoplasmic mRNA processing body assembly →	+0.127	+0.928	<.001	<.001	3	11
LIVER	Regulation of maintenance of sister chromatid cohesion →	+0.115	+0.850	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,502 associations by consensus.

Regulation of transcription initiation by RNA polymerase II by CNOT8 expression — BLOOD_Lymphoma

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